FDA-approved prescription eye drop specifically designed for presbyopia in adults.1,2 A daily first-line treatment for mild-to-moderate patients with presbyopia.1,3

An optimized formulation for presbyopia

Designed to balance efficacy, safety, and tolerability.1,2

Studied

16
Investigational
Formulations

Initially evaluated in two Phase 2b trials2

Tested

>1,000
participants

Tested across Phase 2 studies 009 (N=157) and 010 (N=147), and Phase 3 trials GEMINI 1 (N=323) and GEMINI 2 (N=427)1,2

Evaluated

Mesopic +
photopic

CONDITIONS

Evaluated in both low light (mesopic) and bright light (photopic) conditions in Phase 3 studies3

Arrived at

1.25%
Pilocarpine

Optimized concentration for presbyopia1,2

Delivered with pHastTM technology2

A proprietary vehicle that rapidly adjusts pH and increases corneal penetration*†2,4-6

Based on an in vitro study. Clinical significance is unknown.

* The pH range of VUITYTM in the bottle is between 3.5 and 5.5.1

Illustration of how VUITYTM prescription eyedrop impacts near and intermediate blurry vision due to age-related presbyopia

Shelf-stable pH

All pilocarpine, including VUITY™, is stored at low pH (~pH 4.5) for stability.*7

* The pH range of VUITY™ in the bottle is between 3.5 and 5.5.1

* The pH range of VUITY™ in the bottle is between 3.5 and 5.5.1


Illustration of how VUITYTM prescription eyedrop impacts near and intermediate blurry vision due to age-related presbyopia

The physiological pH of tears (~pH 6.5) was achieved within 60 seconds.4

Rapidly adjusts pH

Within seconds of contacting the ocular surface, VUITY™ starts to adjust to the physiological pH (~pH 6.5) of the tear film.†‡2,4

The physiological pH of tears (~pH 6.5) was achieved within 60 seconds.4


Illustration of how VUITYTM prescription eyedrop impacts near and intermediate blurry vision due to age-related presbyopia

With increased corneal penetration

A neutral pH was associated with increased corneal penetration, improving ocular bioavailability.4-6

 

Dual mechanism of action1

Pilocarpine hydrochloride is a cholinergic muscarinic agonist that activates muscarinic receptors located at smooth muscles such as the iris sphincter muscle and ciliary muscle.1

Primary:
Extends depth of focus
VUITY™ contracts the iris sphincter muscle, constricting the pupil to improve near and intermediate visual acuity while maintaining some pupillary response to light.

Secondary:
Increases the amplitude of accommodation§
VUITY™ also contracts the ciliary muscle and may shift the eye to a more myopic state.

§Accommodation is the ability of the eye to change the refractive power of the lens to automatically focus on objects at various distances. Amplitude of accommodation (AA) is the amount of accommodation exerted to move the focus from the far point to the near point.9

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See how VUITY™ performed in clinical studies